Location

From All Points NORTH
Take I-95 S (toward New York City).
Take the exit onto I-278 W toward Brooklyn/Staten Island and follow it for 3.3 miles.
Take exit 35 for I-495/Long Island Expressway toward Midtown Tunnel and merge onto I-495 W.
Continue NY-495 W and turn right at E 34th Street.
Turn left at the 3rd cross street onto E 37th St
Turn right at Madison Ave and follow it for 0.2 miles.
Take your first left onto 5th Ave
The Langham, New York, Fifth Avenue will be on the right at 400 Fifth Avenue.

From All Points SOUTH
Take I-95 N (toward New York City).
Take exit 16E toward Lincoln Tunnel/NJ-3.
Keep left at the fork and merge onto NJ-495 E.
Take the exit toward 42 Street/I-495 E/New York 9A.
Turn right at W 40th Street and follow it for 0.8 miles.
Turn right at 5th Avenue.
The Langham, New York, Fifth Avenue will be on the right at 400 Fifth Avenue.

From John F. Kennedy (JFK) Airport 
Follow the signs and merge onto to I-678 N for 7.4 miles.
Take exit 12B (I-495 W/Long Island Expressway) toward Midtown Tunnel and continue on I-495 for approximately 7.5 miles.
Turn right at E 34th St and continue for 0.3 miles.
Turn right at Madison Ave and continue for 0.2 miles
Turn left at the 3rd cross street onto E 37th St
Take your first left onto 5th Ave
The Langham, New York, Fifth Avenue will be on the right at 400 Fifth Avenue.

From LaGuardia Airport
Follow the signs toward Grand Central Parkway W and follow it for approximately 0.9 miles.
Take the exit onto Brooklyn Queens Expy E and follow it for 1.2 miles.
Merge onto I-278 W and follow it for 2.2 miles.
Take exit 35 for I-495/Long Island Expressway toward Midtown Tunnel/Eastern Long Island/Greenpoint Ave.
Follow I-495 for approximately 3 miles.
Turn right at E 34th Street and follow it for 0.3 miles.
Turn right at Madison Avenue and follow it for 0.2 miles.
Turn left at the 3rd cross street onto E 37th Street and follow it for 0.1 miles.
Take the 1st left onto 5th Avenue.
The Langham, New York, Fifth Avenue will be on the right at 400 Fifth Avenue.

From Newark Airport
Take US-1 N/US-9 N to I-95N.
Follow I-95N for 5.5 miles.
Take exit 16E toward Lincoln Tunnel/NJ-3 Toll road
Keep left at the fork and follow the signs for N J 3/Secaucus and merge onto NJ-495 E.
From 495 E, take the exit toward 42 St/I-495 E.
Turn right at W 40th St and drive for 0.8 miles.
Turn right at 5th Avenue.
The The Langham, New York, Fifth Avenue will be on the right at 400 Fifth Avenue.

Directions by subway

42ND Street Grand Central Station (S-4-5-6-7-Metro North Railroad)
0.46 miles from 400 Fifth Avenue (approximately 9 minutes walking)
Walk South West towards 400 Fifth Avenue

34TH Street Herald Square Station (B-D-F-M-N-Q-R-W)
0.33 miles from 400 Fifth Avenue (approximately 7 minutes walking)
Walk east towards 400 Fifth

34TH Street Penn Station (1-2-3-Long Island Railroad)
0.49 miles from 400 Fifth Avenue (approximately 10 minutes walking)
Walk east towards 400 Fifth